A Case of Allergic Contact Dermatitis with Diffuse Secondary Eruptions

Abstract

We herein describe a 73-year-old man, who developed diffuse secondary eruptions associated with allergic contact dermatitis. He had applied Astat^® lotion to his feet for tinea pedis. One week later, diffuse secondary eruptions appeared on his trunk. In this patient, the primary lesions became clinically manifest after the development of secondary eruptions. Both a patch test and a lymphocyte stimulation test to Astat^® lotion were positive. In addition, peripheral blood mononuclear cells from the patient also released IFN-γ and IL-5 in response to stimulation with the causative drug. The possible involvement of cytokines in the development of secondary eruptions are also discussed.