Abstract
A case of pemphigoid nodularis is reported. A 42-year-old woman with an 11-year history of pruritic prurigo nodularis-like eruptions on her trunk and extremities developed annular edematous erythema on her thighs and pea-sized tense blisters on her soles. Direct immunofluorescence studies of a prurigo nodularis-like lesion and peribullous skin showed the deposition of IgG and C3 in a linear pattern at the basement membrane zone. Indirect immunofluorescence studies revealed IgG circulating anti-basement membrane zone antibodies. Systemic examinations did not reveal any association with internal malignancies. The systemic administration of cyclosporin A and predonisolone proved to be effective in treating these prurigo nodularis-like eruptions.
