2000 Volume 62 Issue 1 Pages 50-53
We herein report a 69-year-old man with erythroplasia of Queyrat. He noticed a red plaque on his glans penis one year ago. The plaque gradually became enlarged and erosion occurred within the lesion. Histopathologically, disorganization of the epithelium, atypical cells, and several individually keratinized cells appeared throughout the full thickness of the epidermis. No invasion was observed beyond the basement membrane. He was successfully treated by chemotherapy (peplomycin i.m., total 60mg) in combination with radiotherapy (electron beam, total 55Gy) and no recurrence has been observed. A survey of HPV DNA in the lesion was carried out using the in situ hybridization technique, however, no HPV DNA was detected in our patient.
