Abstract
We report a case of multiple cutaneous leiomyomas arising in a 70-year-old Japanese female. She had been suffering from multiple tumors on her trunk for 15 years. The skin lesions gradually increased in size and number. The lesions showed firm, red to brownish colored tumors, of measured up to 6mm in diameter. She had also been suffering from recurrent attacks of severe pain in the lesions. The tumors showed the typical histological findings of leiomyoma, which were well-defined dermal tumors, consisting of spindle cells with characteristic long, thin ’cigarshaped’ nuclei. Ordinary analgesics had no effect on the pain. She was treated with Nifedipine, a calcium channel blocker, for a month. However Nifedipine was not very effective in reducing the pain. Thereafter doxazosin, an alpha adrenoceptor blocker, was given for 3 months to relieve pain. The pain mostly disappeared after this treatment. Surgical excisions were performed on some large tumors. We consider that Doxazosin or Nifedipine may thus be useful for relieving pain from multiple cutaneous leiomyoma due to their ability to relax arrectores pilorum muscle.
