Abstract
A 12-year-old girl with Down syndrome presented with small whitish papules on the dorsum of her hands and feet and syringoma-like structures on the inferior eyelids and cheeks. Histopathological examination of a hand lesion revealed subepidermal calcium deposits with thinned epidermis and foreign body reaction at the bottom of the nodule. Thus, this case was diagnosed as Down syndrome with multiple milia-like calcinosis on the extremities and syringomas.
