Palisaded Encapsulated Neuroma

Abstract

A papule with no subjective symptoms had been present for several years on the left side of the lower jaw in a 66-year-old woman. Histopathological examination revealed a nodular structure in the dermis with a cleft between surrounding tissue, and the nodular structure was composed of nerve bundle-like multiple nodular structure of bundled proliferation of mainly spindle cells. Some of the nuclei of the spindle cells were in palisades and most of them were positive for S-100 protein. Moreover, axons were stained with Bodian stain. Based on these findings, a diagnosis of palisaded encapsulated neuroma was made. Since there have been few reports of this type of neuroma in Japan, the clinical and histopathological characteristics of this neuroma are described with some discussion of the literature.