Abstract
Condyloma acuminatum is caused by mucous-specific types of human papilloma virus infection. Especially, Giant condyloma acuminatum is rare, and in many cases it is very difficult to treat. Zinc oxide starch powder mainly consists of Zinc oxide and starch powder. Zinc oxide provides 1) astringency, 2) a protective effect and 3) an antibiotic effect. Starch powder has an absorbent effect. So we proposed that Zinc oxide powder could change the moist environment in the genital region and that it could suppress a proliferation of virus that would lead to a decrease in the tumor size. Here, we report two cases of Giant condyloma acuminatum of the genital region that were effectively treated with Zinc oxide starch powder. A 20-yearold woman presented with a giant cauliflower-like tumor of the perianal region. She had had treatment with topical 5-fluorouracil for about 1 year. She also had been treated for SLE with corticosteroid. After 8 months treatment with topical Zinc oxide starch powder and administration of coix extract, the tumor disappeared with small scars. Also, a 38-year-old man was hospitalized with a giant cauliflower-like tumor on the penis and in the genital area. We also found that he had severe untreated diabetes. He used to be treated with podophyllin. A partial excision of the lesion was performed. After 7 months of topical application of Zinc oxide starch powder and administration of coix extract, the residual tumor collapsed. We propose that Zinc oxide starch powder is a good treatment option because it is 1) painless, 2) easy to handle by patients, 3) useable with other general treatment options, and also 4) inexpensive and commercially available.
