Abstract
A 52-year-old woman had suffered from Raynaud's symptom for 10 years. A diagnosis of systemic sclerosis (limited type) was made on the basis of clinical and laboratory findings and histopathology of a skin biopsy. The year after diagnosis, she presented with pruritis. Oral administration of antihistamines is temporarily effective against pruritis, but the pruritis recurred 4 months later. Moreover, she noticed erythema on her extremities and swelling on her left upper limb. Laboratory investigation revealed hypereosinophilia, and histological examination showed infiltration of numerous eosinophils in the dermis with prominent flame figure. Based on these findings, a diagnosis of Wells' syndrome with systemic sclerosis was made. Oral corticosteroid was effective, but the erythema and pruritus recurred when administration was stopped or the dose was tapered.
