A Case of Photoleukomelanoderma due to Hydrochlorothiazide Contained in Preminent^®

Abstract

A 75-year-old female had been treated with Nu-Lotan^® (losartanpotassium) for hypertension. One month later, her treatment was changed from Nu-Lotan^® to Preminent^® (losartanpotassium/hydrochlorothiazide) and she developed pruritic edematous erythema on sun-exposed areas. Three month later eruptions appeared and pigmentations and depigmentations developed on the same areas. The minimal erythema dose (MED) of UVA was decreased to 4.4 J/cm². On withdrawal of the Preminent^®, the MED was normalized. We made a diagnosis of photoleukomelanoderma due to hydrochlorothiazide contained in Preminent^®.