Abstract
Xeroderma pigmentosum (XP) is associated with a deficient mechanism for repair of ultraviolet light-induced damage of DNA. The disease includes eight genetically different complementation groups comprising XP-A through-G and the XP variant (XP-V). We report on an 83-year-old man with XP group F (XP-F) disease. He had been sensitive to sunlight since childhood and had pigmentation changes in sun-exposed skin. He was diagnosed as XP-F at the age of 64 years. Despite avoiding sunlight exposure since the diagnosis by using sunscreen or wearing long-sleeved shirts, he developed two squamous cell carcinomas, one basal cell carcinoma and 14 actinic keratoses in the sun-exposed skin during almost 20 years of observation at our hospital. These observations suggest that early diagnosis of XP is important in order to prevent XP-F patients from developing skin cancers.
