Abstract
Pagetoid reticulosis (PR) is a variant of mycosis fungoides (MF) with localized lesion. Previously, disseminated pagetoid reticulosis (DPR) was classified as a variant of PR, with multiple localized lesions. Although the original term PR remained in the 2008 World Health Organization classification, the definition of PR excluded DPR. According to a recent textbook, DPR should be reclassified to classical MF or another lymphoma group, such as aggressive epidermotropic CD8 positive cytotoxic T-cell lymphoma, γδ-T cell lymphoma, or extranodal NK/T cell lymphoma, nasal type. Herein,we report a clinical case of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) with multiple localized lesions and some histopathological similarity with MF. A 42-year-old man visited our department with an 8-month history of asymptomatic erythematous plaques, with one plaque on the left axilla and another on the right lower extremity. Swollen lymph nodes in the left axilla and right inguinal region were palpable at the initial visit. Histopathologically, specimens taken from these lesions revealed dense infiltrations of lymphoid mononuclear cells with atypical nuclei in the epidermis, and in the upper dermis and around the appendages. These findings were similar for MF, but the multiple localized lesions did not match typical MF. In the present case, we excluded the some differential diagnosis, and eventually diagnosed the patient with PTCL-NOS with characteristics of MF. We report the present case and discuss the clinical characteristics and diagnosis for similar cases such as DPR with localized multiple lesions of MF within the literature.
