Abstract
Bipedalism is the hallmark of the family Hominidae. It is thought that the development of bipedal locomotion in Homo sapiens was accompanied by physical immobility of the lumbar spine, leading to lower back pain. The Bone and Joint Decade, which was proposed by the World Health Organisation (WHO), is a worldwide movement extolling the importance of the motor organs in maintaining physical health. Motor organmanaged movement activates the brain and nervous system, and plays an important role in maintaining both circulatory and metabolic health. The purpose of our study was to clarify the causes of lower back pain by analyzing the effects of bipedalism on changes in gene and protein expression in the intervertebral lumbar discs. This was achieved by investigating thses processes in a standing mouse model and approximating the results to the human environment. We are confident that our research will help to furter elucidate the causes of lower back pain.
