Abstract
A twelve years-old girl was sent to our clinic. She had sarcoma-like findings after the fracture of right humerus, and congenital dislocation of bilateral radial heads. Her serum alkaline phosphatase showed high level. Microscopically the tissue surrounding the fracture site seemed to be reactive callus formation, containing giant cells and enchondral ossification. She was treated with corticosteroid, but excessive callus did not cease to grow.
Her father had similar past history i. e. repeated fractures and hyperplastic callus after the fracture. Her aunt also had fracture of right fibula followed by tumor formation at the age of ten years old. Resection of the fibula and surrounding tumor was performed. Microscopic diagnosis by pathologist was chondrosarcoma, but she is now alive fifteen years after the operation.
Other roentogenological findings of this family are thin cortex and radiolucent zone at the metaphysis of long bone in childhood.
