Diagnosis of Chondrosarcoma

Abstract

Recently we have experienced two cases of chondrosarcoma and one of chondroma.
The smears from chondrosarcoma show giant cells containing large nuculei, several nuculei or a number of chromatin chumps. Histochemically tumor cells of chondrosarcoma exhibit alkaline phosphatase activity, on the contrary tumor cells of chondroma do not exhibit alkaline phosphatase activity.
The cells of chondrosarcoma electromicroscopically have the characteristics of the malignant tumors with irregularity and invagination of the nuculear membrane, so called inclusion body in the nuclei, agglomeration of the chromatin, and increase of the free-ribosome and the atypical mitochondria. Smear, Histochemical findings of alkaline phosphatase, electromicroscopical findings are useful in diagnosis of chondrosarcoma.