Ultrastructure of Articular Cartilage of Experimental Osteoarthritis

Abstract

A method is described for producing a slowly progressing osteoarthritis-like condition and permitting examination of even the earliest phases of degeneration of the articular cartilage in rabbit knee joints.
The method consists of making the joint unstable by surgical procedure; this produces a lesion of the same type as found in human osteoarthritis.
Degenerative changes produced was examined photomicrographically and electromicrogr-aphically.