Therapeutic Effects of Iα-OH-D₃ on Vitamin D-resistant Rickets and Vitamin D-dependency

Abstract

A three-year-old boy with vitamin D-dependent rickets had not been well controlled until administration of 1α-OH-D₃ instead of ergocalciferol (VD₂). 1α-OH-D₃ was more effective and more safely used than VD₂, because of less accumulation into the body than VD₂.
By three cases of vitamin D-resistant rickets, administration of 1α-OH-D₃ improved radiological findings preceding the changes of calcium and inorganic phosphorous levels in blood serum. High dose of 1α-OH-D₃ (6-16μg/day) has been used to improve the chemical data in blood serum, especially the regulation of low serum inorganic phosphorous was difficult, because vitamin D-resistant rickets have disorder of phosphate metabolism independent to vitamin D.