Abstract
When fibrinogen coagulates to form fibrin the interlacing fibers of the resultant clot become adhesive. In vivo this make the onset of wound healing. Since 1970, the welding effect of fibrin clots was re-investigated. Before the clinical application, biomechanical examinations, which would investigate the tensile strength of welded nerve or tendon, showed significant strength for glueing nerve anastomoses. Also histological examinations indicated excellent nerve regeneration in the distal nerve segment.
Some clinical cases, which were treated with clotting substances, were reported.
