Immunohistochemical Studies on the Distribution of IL-1 and IL-6 Producing Cells in the Synovial Membranes of Patients with Joint Disorders

Abstract

IL-1 and IL-6 producing cells in synovial tissues obtained from patients with Rheumatoid Arthritis (RA), Osteoarthritis (OA), Avascular Necrosis of the Femoral Head (ANF) and Rapidly Destructive Coxarthrosis (RDC) were observed by immunohistochemical method. Positive staining of IL-1 and IL-6 was seen in the synovial lining cells, vascular endothelial cells and fibroblasts in OA, ANF and RDC synovial tissues as well as RA synovial tissues. The results of immunohistochemistry found necessity to select the area taken from the synovial tissues.