Abstract
We investigated the clinical factors associated with local recurrences in 24 patients with malignant bone tumors, who had undergone tumor resection with a wide surgical margin. Local recurrences occurred in 3 patients with osteosarcoma and one patient with Ewing's sarcoma.
Recurrence was thought to be due to an inadequate surgical margin, and this was probably caused by the following: (1) Reduction of surgical margin after shrinkage of the tumor following preoperative adjuvant treatment, (2) usual wide surgical margin but skip metastases or tumor thrombi suggested by CT scan and MR imaging, and (3) needle biopsy scattering tumor cells into the surrounding soft tissue.
