A case of gastrointestinal stromal tumor with liver and bone metastaseseffectively treated with radiofrequency ablation and imatinib mesylate

Abstract

A 58-year-old man was admitted because of perforation of the small intestine by a gastrointestinal stromal tumor (GIST)D FirstC the small intestine including a GIST was resected;and then 2 month laterC a part of the liver (S5) conforming to metastatic lesion was surgically removed. Twelve months laterC another liver metastases was foundC and surgical treatment was recommended;but the patient requested non-surgical therapyC so a radiofrequency ablation (RFA) was successfully performed. After thatC recurrence of liver metastasis was not observedC but another metastasis was observed on the fifth lumbar vertebra;so administration of imatinib mesylate was started. 28 months after the initial administration the metastatic liver lesion was still invisibleC and the bone metastatic lesion had not grown. The patient is alive with good performance status. This report shows that multi-modality therapy by surgeryC RFA and imatinib mesylate was effective for liver and bone metastases of GIST.