The Study on E. Coli in Human Digestive Tract, at Laparotomy of Surgical Diseases in the Upper Abdomen

Abstract

In a series of 143 selected patients on abdominal surgery, the cholecystic bile, choledochal bile, duodenum, jejunum, ileum and transverse colon contents were collected. From each of the specimens, Escherichia coli were isolated and antibiotic sensitivity of them were determined, and the ecology and physiopathology of E. coil in the human digestive system were discussed.
1) In most of cases in whom E. coli were detected in the biliary tract, E. coli were also detected in the duodenum and jejunum.
2) In the group of stomach cancer, the incidence of E coli in the duodenum was 25%, in jejunum 28.1%, cholecystic bile 8.8% and choledochal bile 3.1%.
3) In the group of peptic ulcer, E. coli were not frequently detected in the upper digestive tract, including biliary tract.
4) The detection rate of E. coli in the terminal ileum is varied with the kinds of disease.
5) There was no difference in the detection rate of E. coli in the transverse colon in all kinds of disease.
6) 68.6% of all isolated strains of E. coli was drug resistant to tetracycline, 66.0% to chloramphenicol, 41.2% to streptomycin, 34.6% to colistin and 31.1% to kanamycin.
7) There was no difference in the drug resistance in all strains of E. coli isolated from different anatomical parts.
8) Two-drug resistant to tetracycline and chloramphenicol was 60.1% with the highest rate, and 27.3% to kanamycin and colistin with the lowest rate.
9) Three-drug resistant to tetracycline, chloramphenicol and streptomycin was 37.1% with the highest rate, and 23.1% to kanamycin, streptomycin and colistin with the lowest rate.
10) Four-drug resistant to tetracycline, chloramphenicol, kanamycin and streptomycin was 26.6% with the highest rate, and 21.7% to kanamycin, streptomycin, colistin and tetracycline with the lowest rate.
11) The resistance to all tested drugs was found in 19.5% of all isolated strains of E. coli.