Micro-angiological studies on the experimental Chronic gastric ulcer

Abstract

Using the experimental chronic gastric ulcer induced by the clamping cortisone method (c-c ulcer by Umehara & Tabayashi), the micro-vascular changes observed during the course of the ulcer and the influence of drugs on the changes were examined.
For observation of the vascular changes, the stomach was infused with India Ink and the stomach preparations were prepared for microscopic study. The results obtained from the c-c ulcers (c-c group), were compared with those of the ulcers induced by clamping alone (the control group), those of the ulcers treated with long term administration of cortisone (the Cr group), those of the ulcers treated with small doses of anabolic steroids (19NAPP) (the D-1 group) and others with large doses (the D-2 groups)
The results of the studies are as follows;
1) Regeneration of the vascular phlexuses in the submucosal layer of the c-c ulcer was remarkably inhibited in the early stage of the ulcer and vasclarization directed toward the base on the ulcer was not found in the c-c ulcer at the same stage.
2) In the c-ulcer, the anastomoses of the blood vessels which regenerated from both sides of the ulcer were formed within in 1 week after making the ulcer, but in the c-c ulcer, these horizontal anastomoses were not formed at such an early stage and a vertical vascularization like a palisade began to be built after the first week. This means that the poor development of the holizontal collagen fibers resulted in reterdation of healing of the ulcer. So that, the ulcer deteriorated and a wide base like a plateau was formed.
3) In the Cr-group, development of the vacslsrization and healing of the ulcers were slower compared with those of the c-c group.
4) In the D-1 group, regeneration of the vascular phlexuses in the submucosal layer began in the early stage. The vascularization directed toward the base of the ulcer and contruction of the ulcer became prominent and healed rapidly. On the other hand, the vascular phlexuses in the submucosal layer of the D-2 group regenerated remarkably in the early stages compared with that of D-1 group, but the healing of the ulcer was not promoted in the middle stage. The prolongation of healing in this groups seemed to be due to the wearing off effect of the steroid.