Effect of Diet on Experimental Pancreatitis and it's repairing Course in rat

Abstract

In order to study the effect of diet on the repairing course of acute pancreatitis, acute pancreatitis was experimentally produced in 130 rats which had been fed on two types of high protein and high fat diet and high carbohydrate diet for four months and comparative biochemical and histological examinations were made on it's repairing course for two months. The following results were obtained. 1. The amount of either mucopolysaccharide or collagen of the pancreas increased in acute phase and from one month after experimentally produced acute pancreatitis in both diet groups. The increasing degree of mucopolysaccharide and collagen were obviously marked in the group of high protein and high fat diet and especially the amount of collagen was increased two months later in the group of high protein and high fat diet. 2. The histologic findings of the pancreas showed the residual figures of inflammation till two weeks after experimentally produced acute pancreatitis in both diet groups. After further longer duration of observation, however, the regeneration of zymogen granules and the increase of fibrosis were marked in the group of high protein and high fat diet while the degree of fibrosis was slight in the group of high carbohydrate diet.
The results above mentioned revealed that the degree of pancreatic damage was severer and the repairing reaction was stronger in the group of high protein and high fat diet than that of high carbohydrate diet. It was assumed that the repeat of acute pancreatitis caused the higher degree of fibrosis in the group of high protein and high fat diet.