Cytological observation of nucleus of atypical epithelium of the stomach

with special reference to differential diagnosis of early cancer

Abstract

The purpose of this study is to compare cytological findings of nucleus of atypical epitheliae of elevated lesions of stomach with that of elevated, well differentiated early gastric cancer. The two groups of 62 cases with atypical epitheliae and 20 cases with well differentiated early gastric cancer of the elevated type were studied. Cytological materials were obtained by direct biopsy method, and cytological slides were prepared by both crushing and rolling-on methods with Papanicolaou staining, and observed microscopically under 1000X magnification. The cytological characteristics of the nucleus are classified into six groups, i, e, size of the nucleus, chromo-center, distribution of chromocenter in the nucleus, nuclear rimbs, nuclear clear area, and color density, of which features were comparatuiely analyzed in the two groups. It may be concluded that differential diagnosis by the intranuclear findings between atypical epitheliae of the elevated lesions in the stomach and cancer cells of the elevated type of the early gastric cancer could be made in the majority of the cases studied.