Basic and Clinical Studies of Malabsnrption Syndrome By Biopsy of Small intestine

With Special Reference to Morphological Changes of Intestinal Villi and Influence of Medium Chain Triglyceride

Abstract

In order to assess the morphological abnomalities of villi in malabsorption syndrome, tissue specimens obtained from jejunum by biopsy were studied by our method of measurement. The influence of administration of the medium chain triglyceride upon the blood lipid components and villi were studied.
Morphological changes of villi were assessed by measurement of the height, width, cut surface and surface area of villi, of which mutual relationships were also evaluated.
In the cases with malabsorption syndrome morphological changes of villi, mainly consisting of atrophy in comparison with those in healthy subjects may be speculated to take place at first probably around the glandular duct.
The decrease of areas of cut surfaces and superficial surfaces may suggest to show the decrease of absorptive area. Administration of medium chain triglyceride for those cases with malabsorption syndrome resulted in improvement of blood lipid abnormality and in recovery of atrophied mucosa. For the treatment of these diseases, medium chain triglyceride appears to be more effective than long chain triglyceride.