Some Observations on the Regenerating Mucosa of the Experimental Gastric Uler in Rats

Abstract

Experimental gastric ulcers were made in rats, and the regeneration of the mucosa was observed by acid phosphatase and beta-glucuronidase staining and mitotic figures were measured by administering colchicine.
In the acute gastric ulcer model, the epithelial ingrowth was formed at the marginal zone of the ulcer, from which the healing mechanisms seemed to be started. While in the chronic ulcer model, regeneration of the mucosa was retarded by that insufficiency.
The epithelial ingrowth is considered to be constituted of dedifferentiated cells from the mature cells and undifferentiated cells rolling down from the neck cells layer in the mucosa to heal the gastric wounds. It is a cell population, having a high potential energy to divide and differentiate, supported by the connective tissues of both the mucosa and base of the ulcer.
It is suggested that lysosomal enzyme acid phosphatase and beta-glucuronidase are concerned with the metabolism just after the cells devided to develop and differentiate normally.