The Effect of the Pancreatic Blood Flow on Exocrine Secretion of the Canine Pancreas

Abstract

In order to study the effect of the pancreatic blood flow on the exocrine secretion of canine pancreas, simultaneous measurements of the blood flow of the inlet artery of the pancreas, the amount of the pancreatic juice and the amylase concentration in pancreatic juice were performed, following the intravenous injection of pancreozymin or secretin. Blood flow of the superior pancreatico-duodenal artery was measured by means of the non-cannulating type of the electromagnetic flowmeter after the ligations of the inferior pancreatico-duodenal artery and some branches of the splenic artery which gave blood supply to the pancreas.
In addition, correlation between the pancreatic blood flow and the exocrine secretion was investigated by increasing the pancreatic blood flow by means of the artificial heart lung apparatus. Following results were obtained.
1) Pancreatic blood flow and exocrine secretion increased significantly in all dogs after the intravenous administration of pancreozymin or secretin.
2) Amount of exocrine secretion of pancreas was correlated well with the pancreatic blood flow when the pancreatic blood flow was increased by means of the artificial heart lung apparatus under the intravenous injection of secretin as background.
3) Amount of the exocrine secretion of pancreas increased significantly by increasing the pancreatic blood flow by means of the artificial heart lung apparatus without the use of any other stimulation.
4) It was considered from the above finding that the change of the pancreatic blood flow had close relation with the exocrine secretion of the pancreas.