Experimental Ulcer-cancer in the Glandular Stomach of Rat

Abstract

Male Wistar rats were fed with 0.1% iodoactamide (IAM) and/or 0.005% (50mg/l) N-methyl-N'-nitro-N-nitrosoguanidine (NG) dissolved in drinking water. IAM induced chronic ulcers in the fundic region along the limiting ridge of the stomach. NG produced carcinomas in the pyloric region but none in the fundic region. The treatment with both of them led to development of cancerous lesions not only in the pyloric region but also in the fundic region which had been ulcerated. The fundic lesions were lower in their incidence and milder in atypia than the pyloric lesions.
The findings suggest that gastric ulcer may be transformed into malignancy but the malignant transformation may occur less frequently than expected in the non-ulcerative and susceptible region.