Influence of bile acids and effect of addition of lecithin thereto on formation of experimental gallstone

Abstract

It was studied what influence bile acids (CDCA, LCA) has and what effect the additionof lecithin to bile acids has on the formation of gallstone in hamsters bred with the diet of highglucose but lacking unsaturated fatty acid. The occurrence rate of gallstone was 75% in thecontrol group, 44% in CDCA (0.05%) administration group, 67% in CDCA (0.1%) administrationgroup, 72% in LCA (0.1%) administration group, 33% in lecithin administrationgroup, 20% in CDCA (0.05%) +lecithin administration group, 27% in CDCA (0.1%) +lecithin administration group.
CDCA produced a dose-dependent difference in the occurrence rate of gallstone. Formationof gallstone was inhibited to some extent by 0.05% CDCA but was not inhibited by 0.1%CDCA. Lecithin used alone produced a higher inhibitory effect on gallstone formationthan CDCA used alone. Addition of lecithin to CDCA, regardless of the dose of CDCA, significantly decreased the occurrence rate with clear potentiation of the inhibitory effectof CDCA on gallstone formation. Also, improvement of cholesterol solubility in bile compositionwas observed in the group of CDCA+lecithin. These suggest the usefulness of theconcomitant use of CDCA and lecithin.