Peutz-Jeghers Syndrome: A Histopathological Study of Its Gastrointestinal Polyps

Abstract

Histopathologically were examined polyps of fifteen cases, diagnosed as Peutz-Jegherssyndrome. Similar hsitological pictures were shown on the polyps in each segment of thegastointestinal tract.
In gastric lesions, foveolar epithelial hyperplasia is predominant and foveolae are frequentlyelongated and cystically dilated. In those of the small intestine were seen three kind of cells, such as columnar absorbing cells, goblet cells and Paneth cells. Lieberkiihn's glands don'tappear to be involved. Paneth cells are noted rather at the bottom of the crypts. In thecolon, goblet cell hyperplasia is dominant.
Concerning malignant transformation of Peutz-eghers polyps, no malignancies wereseen in gastric ones. Distinctive cancerization was observed in a polyp of a case, and penetrationof glands into the wall, from submucosa to the subserosa, was noted in polyps of six cases, in the small intestine. In those of the colon no malignant degeneration was observed.
It may be possible histologically to distinguish polyps in Peutz-Jeghers syndrome fromother forms of gastrointestinal polyposis.