血中にα-Fetoprotein, CEA, variant alkaline phosphatase の共存を認めた肝転移を有する胃癌の1症例 各癌関連胎児性蛋白の臓器由来について

沖田 極; 野田 健一; 早川 幹夫; 児玉 隆浩; 武波 俊彦; 福本 陽平; 藤井 良子; 河原 清博; 伊達 敏明; 岡崎 幸紀; 西村 秀男; 竹本 忠良

doi:10.11405/nisshoshi1964.75.224

A CASE OF GASTRIC CARCINOMA WHOSE SERUM WAS POSITIVE FOR ALPHA-FETOPROTEIN, VARIANT ALKALINE PHOSPHATASE AND CEA

Kiwamu OKITA, Ken-ichi NODA, Mikio HAYAKAWA, Takahiro KODAMA, Toshihiko TAKENAMI, Yohei FUKUMOTO, Ryoko FUJII, Kiyohiro KAWAHARA, Toshiaki DATE, Yukinori OKAZAKI, Hideo NISHIMURA, Tadayoshi TAKEMOTO

Author information

Kiwamu OKITA
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Ken-ichi NODA
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Mikio HAYAKAWA
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Takahiro KODAMA
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Toshihiko TAKENAMI
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Yohei FUKUMOTO
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Ryoko FUJII
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Kiyohiro KAWAHARA
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Toshiaki DATE
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Yukinori OKAZAKI
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Hideo NISHIMURA
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine
Tadayoshi TAKEMOTO
First Division, Department of Internal Medicine, Yamaguchi University School of Medicine

Keywords: α-fetoprotein (AFP), alkaline phosphatase (AlK.P), variant AlK.P, carcino-embryonic antigen (CEA)

JOURNAL FREE ACCESS

1978 Volume 75 Issue 2 Pages 224-231

DOI https://doi.org/10.11405/nisshoshi1964.75.224

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Abstract

A case of 78-year old man, who was diagnosed of gastric cancer metastatic to the liver and whose serum revealed the presence of 3 different carcinofetal antigens such as alpha-fetoprotein, variant alkaline phosphatase and carcino-embryonic antigen(CEA), was reported. In this case, alphafetoprotein producing cells seemed to be degenerating hepatocytes which were compressed by metastasis. Although synthesizing cells of variant alkaline phosphatase and CEA were studied biochemically using the extracts from the liver free from the cancer and gastric cancer, it was failed to make clear these synthesizing cells because of much contamination of the blood. However, alkaline phosphatase zymogram of the both extracts after treatment with neuroaminidase showed copresence of variant and fetal intestinal alkaline phosphatase which was firstly reported by Higashino et al.
As the conclusion, we want to point out now a time for making clear the synthesizing cells of carcino-fetal proteins, although of course these proteins play an important role in clinical fields.

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