GLUCOSE METABOLISM ON INTRAVENOUS GLUCOSE TOLERANCE TEST IN OBSTRUCTIVE JAUNDICE

Abstract

Intravenous glucose tolerance test was performed in sixteen cases with obstructive jaundice and in thirteen normal persons as control.
Jaundice group showed higher fasting blood sugar level, and after glucose injection there were glucose intolerance and poor insulin reponse of the early phase.
In this group, serum potassium level decreased after glucose injection and did not return to the fasting level even 120 minutes after. Serum inorganic phosphorus level decreased after glucose injection in both groups, but that of jaundice group was higher during the observation, with low reduction rate.
Fasting blood cortisol and cathecolamines level were higher but decreased much more after glucose injection than those in control group.
In is concluded that glucose intolerance in obstructive jaundice is closely related to the accelerated glycogienolysis or gluconeogeness based on poor insulin response, lowed serum potassium, elevated serum inorganic phosphorus and abnormal adrenal function.