PREGNANCY, DELIVERY IN PATIENT WITH ULCERATIVE COLITIS

Abstract

Ulcerative colitis has been recognized since at least 1859, but is of unknown etiology, its course is uncertain and predictable, and its responses to medical and surgical treatment are variable.
Recently, the possible role of immunological mechanisms in the pathogenesis of inflammatory bowel disease has recieved interesting attention.
Ulcerative colitis in women is predominantly seen in the child-bearing period, and its association with pregnancy and delivery is an important matters.
Clinical studies of pregnant patients with ulcerative colitis were performed in three cases (5 delivery cases).
Three patients in whom the onset of ulcerative colitis occured during pregnancy, and aggravated.
Two patients in whom the onset of ulcerative colitis occured in the postpartum period.
Salicylazosulphapyridine (SASP) was used for all cases.
From our clinical results, we persuade the patient with ulcerative colitis to be formidable the risk of aggravating her colitis and the pregnancy should not be undertaken unless the disease has remitted for at least one year. And the events of previous pregnancies are not a reliable guide in future.
The medical drugs should make an effort to avoid or to minimized during pregnancy.
SASP is well tolerated in majority of patient, and we consider it preferable to corticoid in the medical management of the pregnant mother whose colitis is active or occured at the same time of pregnanty.