GASTRIC PEPSIN ACID CORRELATION IN PATIENTS WITH ZOLLINGER-ELLISON SYNDROME

Abstract

Gastric pepsin and acid secretion, and pepsin acid correlation were studied in three patients with Zollinger-Ellison syndrome (ZES). The results were obtained as follows. In all nocturnal secretion and histamine-, insulin- and gastrin-stimulated secretions, pepsin hypersecretion was not conspicuous as acid hypersecretion, and so pepsin acid correlation showed low level of less than 1.0. Not only before operation but also after vagotomy or gastroectomy, the same results were obtained. These results suggest that both before and after operation ZES should be suspected in the patients with pepsin acid correlation of less than 1.0. in nocturnal secretion or stimulated secretion.