EXPERIMENTAL STUDIES ON ACUTE GASTRIC MUCOSAL LESIONS ACCOMPANIED WITH ACUTE PANCREATITIS

Abstract

In order to ascertain acute gastric mucosal lesions accompanied with acute pancreatitis, we studied the pathophysiology of experimentally induced acute pancreatitis in rats. Experimental acute pancreatitis was induced with ligation of the distal part of the common bile duct. The increase of the values of serum amylase and lipase and histologic findings of pancreas demonstrated the occurrence of acute pancreatitis soon after ligation of the distal part of the common blie duct. At this early stage, there were no marked lesions in the stomach. However, aspirin induced ulcers in acute pancreatitis group were aggravated with statistical significance compared with those of the group of no surgical procedure except laparotomy. Gastric mucosal blood flow and pancreatic blood flow were measured simultaneously with hydrogen gas clearance technique until 4 hours after ligation of the distal part of the common bile duct. Pancreatic blood flow decreased with the development of acute pancreatitis. Moreover, marked decrease of gastric mucosal blood flow was observed. At the time 4 hours after ligation of the distal part of the common bile duct, gastric mucosal blood flow decreased to about 50% compared with the value before ligation. We thought that the fragility of gastric mucosa was based on this marked decrease of gastric mucosal blood flow. Moreover, it was demonstrated that the intravenous administration with 10mg/kg of cimetidine improved the decreased gastric mucosal blood flow associated with experimental acute pancreatitis, and clinical usefulness of this drug was suggested.