PANCREATIC STONES DISSOLUTION WITH DIMETHADIONE (DMO)

II. Roentgenological Follow-up Study in Canine Experimental Pancreatic Stones

Abstract

This paper is a sequel to our previous report concerning pancreatic stones dissolution with Dimethadione (DMO). The effect of DMO on the stones dissolution was studied roentgenologically in dogs prepared with both gastric fistula and complete obstruction of the greater pancreatic duct, setting markers of a stainless steel wire around the pancreatoduodenal junctions. Abdominal plain films were taken once a month from three months after the operation.
Pancreatic calcifications were observed in 50% of the dogs (9 of 18). Trimethadione (TMD), the precursor of DMO, was given orally at a dose of 1000 to 1500mg/day to seven dogs presented with pancreatic calcifications. In all but one dog the calcifications disappeared completely or partially in 1 to 10 months after the administration of TMD. In one of two dogs in which the calcifications disappeared completely within two months, the calcifications reappeared two months after the cessation of the dose and again disappeared completely three months after the readministration of TMD. In another dog the calcifications reappeared seven months after the cessation of the dose. Without any treatment of TMD the calcification was gradually increased in its size and number in one dog.
The present results suggest that TMD, as a precursor of DMO, can become one of the promising agents for the oral dissolution of pancreatic stones.