INFLUENCE OF VARIOUS FOOD STIMULI ON SERUM GROUP 1 PEPSIONGEN (PG 1) LEVEL WITH REFERENCE TO GASTRIC SECRETORY FUNCTION

Abstract

A significant correlation has been found between serum PG 1 and gastric secretory function such as basal acid output (BAO), maximal acid output (MAO), basal pepsin output (BPO) and stimulated pepsin output (SPO) in patients of peptic ulcer. The various feeding tests in healthy volunteers revealed no significant response of serum PG 1 level to the stimuli used, although the tendency of increase was found. Neither protein meal nor fatty meal showed any certain effect on serum PG 1 level. In sham-feeding test, serum PG 1 was increased five minutes after stimulation but rather depressed by pretreated with atropine (1mg) without statistical significance. It was concluded that serum PG 1 can be used as a good marker of gastric secretory function although the releasing mechanism of serum PG 1 into blood circulation remained uncertain.