1986 Volume 83 Issue 4 Pages 759-763
At present, the effect of anti ulcer drugs is evaluated simply by calculating the cumulative healing rate at a certain period of the treatment, which does not implicate any analysis of healing speed.
Here, a new method of statistical analysis of ulcer healing speed is hypothetically introduced.
A non-linear regression analysis is performed between two variables t (period of observation) and y (non-healing rate), obtaining an exponential function y=Ae-kt. Practically, the equation is, y=100: 0_??_t<Ti, y=100e-k(t-Ti): Ti_??_t.
The theoretical values obtained from the equation are very much close to the observed values. The regression parameters are defined as follows; k: healing rate constant, Ti: initiation time of clinical healing, T1/2: half-life of non-healing rate, T50: time of 50% healing.
With this method, the effect of drugs on ulcer healing is dynamically analyzed, being expressed by digital parameters with regard to healing speed.