Duodenogastric reflux and gastric carcinogenesis in rats

Abstract

This study was designed to investigate the role of duodenogastric reflux in the genesis of gastric carcinoma in rats. One hundred and two rats were subjected to one of following three surgical procedures: Antiperistaltic duodenogastric reflux (ADGR) was made for duodenal juice to reflux through the pylorus into the stomach. Isoperistaltic duodenogastric reflux (IDGR) was prepared for duodenal juice to reflux into the stomach through the gastrojejunostomy made at the greater curvature of the fundus. Simple laparotomy was employed as control. On the 50th postoperative week all surviving animals were killed and examined. No carcinoma was found in any of the 20 control animals. In seven of 17 animals (41%) with ADGR and five of 13(31%) with IDGR, carcinoma developed in the glandular stomach. The significant difference between ADGR and control group, and IDGR and control group was recognized at the incidence of occurrence of gastric cancer, respectively (P<0.01). The carcinomas were located at the prepyloric antrum in ADGR and at the fundus neighbouring gastrojejunal anastomosis in IDGR. The findings suggests that duodenogastric refulx may be an important factor in gastric carcinogenesis.