Journal of Nihon University Medical Association
Online ISSN : 1884-0779
Print ISSN : 0029-0424
ISSN-L : 0029-0424
Clinical Reports:
A Case of Advanced Gastric Cancer Responding Completely to Neoadjuvant Chemotherapy with S-1 and Cisplatin
Yuki Kimura, Noriaki Kanamori, Takeshi Yokoyama, Kei Iwasaki, Katsumi Yoshii, Kazuyuki Tomioka, Yoshio Kobari, Tadatoshi Takayama
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Keywords: gastric cancer, pancreas invasion, neoadjuvant chemotherapy (NAC), TS-1/CDDP combination chemotherapy, complete response
JOURNAL FREE ACCESS

2012 Volume 71 Issue 2 Pages 129-132

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Abstract
The patient was a 73-year-old man with advanced gastric cancer. Because of invasion to pancreas, we initiated neoadjuvant chemotherapy (NAC) with S-1 and cisplatin (CDDP), and anticipated down-staging of the tumor. After 3 cycles of this regimen, we performed a total gastrectomy with lymph node dissection (D2). Microscopic findings revealed remarkable fibrous changes and no cancer cells in the gastric wall and lymph nodes, which were judged to be a Grade 3 effect (Complete response). This case suggested that S-1/CDDP combination chemotherapy may be useful in treating patients with advanced gastric cancer.
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© 2012 The Nihon University Medical Association
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