Non-Contact Mapping of the Origin of Provoked Ventricular Tachycardia in Brugada Syndrome

Ohkubo Kimie; Watanabe Ichiro; Okumura Yasuo; Sasaki Naoko; Sonoda Kazumasa; Kogawa Rikitake; Takahashi Keiko; Iso Kazuki; Kofune Masayoshi; Nakai Toshiko; Hirayama Atsushi

doi:10.4264/numa.73.91

Original Article:

Non-Contact Mapping of the Origin of Provoked Ventricular Tachycardia in Brugada Syndrome

Kimie Ohkubo, Ichiro Watanabe, Yasuo Okumura, Naoko Sasaki, Kazumasa Sonoda, Rikitake Kogawa, Keiko Takahashi, Kazuki Iso, Masayoshi Kofune, Toshiko Nakai, Atsushi Hirayama

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Keywords: Brugada syndrome, non-contact mapping, electrophysiologic study, ventricular tachycardia, ventricular fibrillation

JOURNAL FREE ACCESS

2014 Volume 73 Issue 2 Pages 91-94

DOI https://doi.org/10.4264/numa.73.91

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Abstract

The pathophysiological basis of Brugada syndrome (BrS) remains controversial. We attempted to isolate the origin of provoked ventricular tachycardia/ventricular fibrillation (VT/VF) associated with BrS through noncontact mapping of the right ventricle (RV). Programmed ventricular stimulation was performed in 3 patients with BrS. Rapid VT of a similar morphology that degenerated into VF was induced from the RV apex (n = 2) or RV outflow tract (RVOT, n = 1). These VTs arose from the RVOT wall or the RV free wall. The RV as the primary origin of VT may be a key target for BrS therapies.

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