A Case of Angiosarcoma of the Scalp with Invasion to the Pleural Effusion

-Diagnosis by Cytology with Immunohistological Examination

Abstract

Angiosarcoma is a rare and high-grade malignancy lesion that occurs in the skin including scalp and soft tissues. We present a case of a 70-year-old man who exhibited angiosarcoma of the scalp and was revealed to have metastasis to the lung and the pleura by cytological examination after excision of the lesion. Cytological examination of the pleural fluid showed the following atypical cellular features; signet ring-like cells, intracytoplasmic lumina-like or hobnail cell cluster and a whorl-like pattern. Immunohistochemically, the atypical cells were positive for CD31, D2-40 and vimentin, and negative for CD34, TTF-1, calretinin and CEA. The clinical and cytological findings were consistent with metastatic angiosarcoma. Despite treatments, the patient expired due to respiratory failure, 11 months after the first medical examination.