2017 Volume 76 Issue 5 Pages 209-213
Herein, we report an autopsy case of sporadic Parkinson‘s disease (PD). An 80-year-old woman was noted to have right hemi-tremor when she was 63 years old, and was diagnosed with PD at 66 years of age. In the interim, she experienced visual hallucinations and bone fractures twice because of falls. Her general cognition was normal. She was admitted to our hospital because of dyspnea. Although she was treated with antimicrobial agents, death ensued. Upon autopsy, diffuse alveolar damage was evident and was considered to be the cause of death. Macroscopic examination of the brain revealed that the substantia nigra and locus coeruleus were pale. Upon histological examination, accumulation of alpha-synuclein was observed in the substantia nigra, locus coeruleus, the dorsal nuclei of the vagus, and other neuronal tissues.