Journal of Nihon University Medical Association
Online ISSN : 1884-0779
Print ISSN : 0029-0424
ISSN-L : 0029-0424
Original Articles:
The Importance of Monitoring Cardiac Function by Echocardiography to Detect Real-World Breast-Cancer-Therapy-Related Cardiotoxicity
Naotaka UchidaTetsuro OhtaSeiji OkadaKimiko HiroeYasuki MatsuiTakeshi Notsu
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2018 Volume 77 Issue 4 Pages 237-243


Background: Breast cancer treatments carry the risk of cardiac problems that may impact the patient’s overall outcome. We aimed to assess the real-world incidence of chemotherapy-related cardiotoxicity and the effect of echocardiographic monitoring of cardiac function in breast cancer patients undergoing chemotherapy. Methods: We assessed patients with breast cancer at our institution who were first treated with anthracycline or trastuzumab between 2008 and 2016. Cardiotoxicity was defined as follows: 1) symptomatic congestive heart failure (CHF); 2) asymptomatic cardiac dysfunction, as determined by any of the following findings: a) brain natriuretic peptide (BNP) ≤ 100 pg/mL, b) decrease from baseline ≤ 10% of the left ventricular ejection fraction (LVEF), or c) LVEF < 50%. We defined the patients from 2014 onward, who had mostly undergone cardiac function monitoring by echocardiography prior to the initiation of the complete regimen, and every 3 months during chemotherapy, as the active monitoring group. Results: After a median follow-up of 4 years, 11 of 118 (9.3%) patients developed cardiotoxicity. Cardiotoxicity occurred more frequently in patients who received trastuzumab; particularly in those patients treated with anthracycline and sequential trastuzumab. Asymptomatic cardiotoxicity was detected first in all cases. Two (1.6%) patients with irreversible cardiotoxicity received anthracycline. Forty-two of 118 patients (36%) underwent active monitoring. Of these 42 patients, 27 (64%) underwent baseline echocardiography to assess cardiac function. A significantly higher proportion of patients undergoing active monitoring received human epidermal growth factor 2 receptor (HER2) targeted agents and a higher dose of anthracycline compared with those patients who were not monitored actively. Cardiotoxicity was identified significantly earlier (median: 1.5 year vs. 5.2 years) in patients undergoing active monitoring than in those not undergoing active monitoring. Conclusion: Echocardiographic monitoring of cardiac function in breast cancer patients undergoing chemotherapy allows early detection of asymptomatic chemotherapy-related cardiotoxicity.

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