Successful Management of a Patient with Multiple Nucleos(t)ide Analogue-Resistant Hepatitis B Virus and Diffuse Large B Cell Lymphoma Using Tenofovir Disoproxil Fumarate: A Case Report

Mizutani Taku; Matsuoka Shunichi; Kikuta Daiichirou; Hayama Jou; Nagai Shintaro; Matsumoto Naoki; Nakamura Hitomi; Nirei Kazushige; Kanda Tatsuo; Moriyama Mitsuhiko; Miura Katsuhiro; Takei Masami; Sugitani Masahiko

doi:10.4264/numa.78.5_295

Case Reports:

Successful Management of a Patient with Multiple Nucleos(t)ide Analogue-Resistant Hepatitis B Virus and Diffuse Large B Cell Lymphoma Using Tenofovir Disoproxil Fumarate: A Case Report

Taku Mizutani, Shunichi Matsuoka, Daiichirou Kikuta, Jou Hayama, Shintaro Nagai, Naoki Matsumoto, Hitomi Nakamura, Kazushige Nirei, Tatsuo Kanda, Mitsuhiko Moriyama, Katsuhiro Miura, Masami Takei, Masahiko Sugitani

Author information

Taku Mizutani [Japan]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Shunichi Matsuoka [Japan]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Daiichirou Kikuta [Japan]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Jou Hayama [Japan]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Shintaro Nagai [Japan]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Naoki Matsumoto [Japan]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Hitomi Nakamura [Japan]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Kazushige Nirei [Japan]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Tatsuo Kanda [Japan]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Mitsuhiko Moriyama [Japan]
Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Katsuhiro Miura [Japan]
Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Masami Takei [Japan]
Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan [Japan]
Masahiko Sugitani [Japan]
Department of Pathology, Nihon University School of Medicine, Tokyo, Japan [Japan]

Keywords: chronic hepatitis B, multiple drug resistance, rituximab, lymphoma, tenofovir disoproxil fumarate

JOURNAL FREE ACCESS

2019 Volume 78 Issue 5 Pages 295-300

DOI https://doi.org/10.4264/numa.78.5_295

Details

Abstract

Background: Malignant lymphoma is occasionally observed in chronic hepatitis B virus (HBV)-infected patients. The occurrence of HBV reactivation or acute exacerbation of chronic hepatitis B during and after chemotherapy and immunosuppressive therapies is a major issue. Case presentation: We reported a 65-year-old Japanese man with multiple nucleos(t)ide analogue (NUC)- resistant HBV infection and diffuse large B cell lymphoma (DLBCL), stage IV. The patient was treated with the addition of tenofovir disoproxil fumarate to entecavir and chemotherapy to control the HBV and treatment of lymphoma, respectively. Both diseases were safely controlled. Conclusion: Clinicians should pay careful attention to NUC-resistant HBV and select the proper NUCs to control the virus before and during the commencement of chemotherapy.

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