Journal of Nihon University Medical Association
Online ISSN : 1884-0779
Print ISSN : 0029-0424
ISSN-L : 0029-0424
Special Articles: Heart Failure
Pharmacological Treatment of Chronic Heart Failure
Kazuto Toyama
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2020 Volume 79 Issue 4 Pages 209-215

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Abstract
Heart failure is a clinical syndrome, which is characterized by symptoms such as breathlessness, fatigue, and edema that appear as a result of decompensation in cardiac function, due to a structural and/or functional cardiac abnormality, and is accompanied by a decrease in exercise tolerance. Heart failure is a progressive and poor-prognosis syndrome, which thus requires not only drug treatment but also comprehensive medical treatment, such as diet therapy and exercise therapy, combined with cardiac rehabilitation. In addition, the number of elderly patients with heart failure will increase in the future, which is called a heart failure pandemic; therefore, it is necessary to provide medical care based on symptoms while also considering palliative medicine and views on life. Previously, The Japanese Circulation Society classified heart failure into acute and chronic categories, with specific guidelines for each. However, both acute and chronic conditions are considered a series of heart failure stages, and revisions have been made for early intervention based on heart failure stages. Regarding chronic phase management of heart failure, the treatment and evaluation method clinically change depending on left ventricular function, and the latest heart failure therapeutic agents are described with reference to the evidence. The targets of heart failure management are to prevent death and control heart failure hospitalizations, which are the endpoints of many large clinical trials, but it is also important to improve the exercise capacity and quality of life (QOL). The role of practitioners and medical cooperation with clinics are extremely important.
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