2026 Volume 2 Issue 1 Pages 278-287
Background: This case series examined whether fluctuations in glycemic dynamics may contribute to irritability and school refusal in children who responded poorly to psychotropic medication.
Case: Case 1 was a 12-year-old boy with autism spectrum disorder, severe sleep-onset insomnia, and frequent tantrums; meals were dominated by refined carbohydrates. Case 2 was an 11-year-old boy with interpersonal hypersensitivity and school reluctance who routi nely ate an entire cake after dinner. Case 3 was a 13-year-old boy with morning headache, orthostatic symptoms, and school refusal; a bdominal pain, cold sweating, and somnolence occurred within minutes after breakfast. Carbohydrat e-focused eating patterns were modified by reducing excessive sweets and adjusting staple portions while increasing protein sources.
Conclusion: All three children showed marked improvement after dietary modification, including r apid resumption of school attendance in Cases 2 and 3. These observations suggest that abnormal glycemic dynamics may be associated with behavioral and emotional instability in medication-resist ant pediatric cases.
