Three Case Reports of Migraine Symptom Improvement Following VitaminD Supple-mentation
2026 Volume 2 Issue 1 Pages 292-302
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2026 Volume 2 Issue 1 Pages 292-302
Background: Migraine is a common primary headache disorder, and preventive options remain li mited. Associations between vitamin D and migraine have been reported but remain inconclusive.
Case: We report three patients with migraine and low vitamin D levels.
Case 1 was a premenopausal woman with non-anemic iron deficiency and premenstrual symptoms. Combined iron and vitamin D supplementation (25(OH)D ≥40 ng/mL, ferritin ≥50 ng/mL) markedl y reduced non-menstrual attacks and improved PMS.
Case 2 was a man without iron deficiency; after psychiatric stabilization, vitamin D supplementati on (2000 IU/day) increased 25(OH)D above 40 ng/mL and nearly eliminated attacks.
Case 3 was a postmenopausal woman with chronic migraine and NSAID overuse; Goshuyuto was effective but discontinued due to liver injury, and escalation of vitamin D to 3000 IU/day (25(O H)D 47.7 ng/mL) resulted in marked reduction of attacks without preventive drugs.
Conclusion: Across these three cases, migraine frequency decreased after achieving 25(OH)D ≥40 ng/mL, with iron correction required in the premenopausal woman. Nutritional assessment may be a useful adjunct in migraine management.
