2018 Volume 50 Issue 1 Pages 44-49
Objective: The therapeutic and medical social effects of ketogenic diet (KD) in children with epilepsy were examined. Methods: A retrospective study was conducted in 53 patients (mean start age 8.2 months, range 0.1-50 months) with intractable epielpsy, who were treated by KD with ketone formula. Results: Seizure-free rate was 11.3% (6/53) in all patients, 100% (3/3) in glucose trasporter 1 deficiency syndrome (GT-1D) patients, 16.7% (1/6) in syptomatic generalized epilepsy patients, and 13.3% (2/15) in symptomatic localization-related epilepsy patients. The proportion of patients who continued KD was 34% (18/53) in all patients, 100% (3/3) in patients with GT-1D, 50% (3/6) in patients with symptomatic generalized epilepsy, and 30% (3/10) in patients with Dravet syndrome. The duration (mean±SD) of KD was 663.0±717.3 days. After the initiation of KD, hospital stay, visit of emergency ambulance, and use of ambulance car were reduced, and days of attending school, kindergarten, etc. were increased in some patients. Motor developmental score increased in 8 patients, and cognitive developmental score in 7 patients. Conclusions: Use of KD in children was effective for inhibition of epileptic seizures in some patients with intractable epilepsy
