Clinical study of oral midazolam solution used as prehospital treatment

Abstract

  Oral midazolam solution, used as prehospital treatment for children with status epilepticus, showed efficacy on 36/50 occasions (72%), with an average time of 4.6 minutes of seizure cessation. Responsive cases had a higher proportion of patients who adhered to the prescribed dose than non-effective cases (p=0.047). Respiratory depression was observed on one occasion (2%). Oral midazolam solution is a fast-acting and highly effective treatment ; however, adverse events such as respiratory depression should be noted.